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Antibiotic is compound one type, good experience of and also synthetic, having effect depress or discontinue a biochemical process in organism, especially in course of infection by virus or bacterium. Usage of antibiotic specially relate to medication of disease of infection, though in engineering and biotechnology of genetic is also used as by appliance select to or mutant of transform an. Antibiotic work like pesticide by depressing or breaking one metabolism link, just only is of its goals is bacterium. Antibiotic differ from disinfectant because way of its job activity. Disinfectant kill germ by creating factious environment to germ for life.

Invention of antibiotic happened ' involuntarily' when Alexander Fleming, in the year 1928, forgetting to clean supply of bacterium at solder cup and leaving it in rack clean as long as weekend. On Monday, when the solder cup will be cleaned, he see some of mould have growled in shares and media around mould ' clean' of previous bacterium fulfill media. Because interesting with this fact, he do conduct furthermore research to mould, which actually is Penicillium sync chrysogenum P. notate ( this young blue chromatic mould is easy to found by at damp let bread of few days). He then gets positive result in examination of influence of that mould extract to its collection bacterium. From that extract is he is confessed to find first natural antibiotic: penicillin of G

Invention of effect anti bacterium of previous Penicillium have been known by researchers of Institute Pasteurize in Prances by the end of century of 19 but its result of non-recognition by its own institute and don’t publication.

KINDS OF ANTIBIOTIC
Antibiotic can be classified pursuant to target work the compound and its formation of him. There is s ix group of antibiotic [1] seen from job activity target (its goals) :

Synthesis bacterium cell wall Inhibitor, including faction of Penicillin, Polypeptide and of Cephalosporin, for example ampicillin, penicillin of G;Inhibitor Transcripts and of replicas, including faction of Quinolone, for example rifampicin, D actinomycin, acid nalidixic;

Synthesis protein Inhibitor, including many type of antibiotic, especially from faction of Macrolide, Amino glycoside, and Tetracycline, for example gentamycin, chloramphenicol, kanamycin, streptomycin, tetracycline, ox tetracycline; Function cell membrane Inhibitor, for example ionomycin, valinomycin;

Other Function cell Inhibitor, like faction of sulfa sulphonamide or, for example oligomycin, tunicamycin; and Antimetabolit, for example passerine.


USAGE OF ANTIBIOTIC
Because usually antibiotic work very specific at one particular process, mutation which possible happened at conducive bacterium of appearance of strain bacterium which ' tie' to antibiotic. That is why, gift giving of antibiotic is usually given in dose causing bacterium immediately die and longish within so that mutation don’t happened. Usage of antibiotic which ' account' only opening opportunity of bacterium type appearance which ' ties

Usage of antibiotic in agriculture area as limited antibacterial generally because assumed is costly, but in its usage biotechnology enough wide of to select pregnant cells of new gene. Practice usage of this antibiotic is criticized sharply by all environmental activist because care of pest appearance which will hold up antibiotic.